Journal: Oxidative Medicine and Cellular Longevity

Article Title: Curcumin, Alone or in Combination with Aminoguanidine, Increases Antioxidant Defenses and Glycation Product Detoxification in Streptozotocin-Diabetic Rats: A Therapeutic Strategy to Mitigate Glycoxidative Stress

doi: 10.1155/2020/1036360

Figure Lengend Snippet: Biochemical parameters of streptozotocin-induced diabetic rats after 45 days of treatment with yoghurt enriched with curcumin, alone or in combination with aminoguanidine.

Article Snippet: After that, rats were euthanized by decapitation and blood samples were collected for the analysis of glycated hemoglobin (HbA1c); for the plasma levels of glucose, fructosamine, triglycerides, and total cholesterol (Labtest Diagnostica SA, Lagoa Santa, Minas Gerais, Brazil); for the measurement of biomarkers of glycoxidative damage [thiobarbituric acid reactive substances (TBARS), protein carbonyl groups (PCO), fluorescent AGEs, and total nitrate and nitrite (NO x )] and of the activities of antioxidant enzyme paraoxonase 1 (PON 1).

Techniques:

Journal: Oncotarget

Article Title: Acute atorvastatin treatment restores the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats

doi: 10.18632/oncotarget.19232

Figure Lengend Snippet: Ingredients of the standard rodent chow and the cholesterol enriched diet used in the current study

Article Snippet: Plasma cholesterol levels were determined following manufacturer guidelines (Diasys Diagnostic Systems GmbH, Holz-Heim, Germany).

Techniques:

Journal: Diabetology & Metabolic Syndrome

Article Title: Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats

doi: 10.1186/s13098-019-0431-0

Figure Lengend Snippet: Biochemical and oxidative stress biomarkers of STZ-diabetic rats treated with curcumin alone or combined with metformin. Plasma levels of glucose ( A ), triacylglycerol ( B ), cholesterol ( C ), TBARS ( D ), fluorescent AGEs ( E ), and PON 1 activity ( F ). Values are expressed as mean ± SEM, n = 10. NYOG: normal rats treated with yoghurt; DYOG: diabetic rats treated with yoghurt; DINS: diabetic rats treated with 4 U/day insulin; DC 90 : diabetic rats treated with 90 mg/kg curcumin in yoghurt; DM 250 : diabetic rats treated with 250 mg/kg metformin in yoghurt; DC 90 M 250 : diabetic rats treated with 90 mg/kg curcumin + 250 mg/kg metformin in yoghurt. The differences between groups were considered significant at p < 0.05 and were analyzed using one-way ANOVA followed by Student–Newman–Keuls test. a Differences with NYOG; b differences with DYOG; c differences with DINS; d differences with DC 90 ; e differences with DM 250 ; f differences with DC 90 DM 250

Article Snippet: At the end of the treatments, the blood samples were collected for the analysis of plasma levels of glucose, triacylglycerol, cholesterol (Labtest Diagnostica SA, Lagoa Santa, Minas Gerais, Brazil), and for the measurement of thiobarbituric acid reactive substances (TBARS), fluorescent advanced glycation end products (AGEs), and the activity of the antioxidant enzyme paraoxonase 1 (PON 1).

Techniques: Clinical Proteomics, Activity Assay

Journal: Journal of Translational Medicine

Article Title: Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and up-regulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: Is that a latent disadvantage?

doi: 10.1186/1479-5876-9-176

Figure Lengend Snippet: Fenofibrate alleviates dyslipidemia in obese MSG rats . Fasting cholesterol, triglyceride and major lipoproteins levels were assayed on 4th week. Nor, normal rats. Con, water treated obese MSG rats. Fen, fenofibrate treated obese MSG rats. Values represented means ± s.e.m. (n = 10-12). *p < 0.05, **p < 0.01, ***p < 0.001 vs. control.

Article Snippet: Plasma glucose was measured by the glucose oxidase method, and plasma levels of triglycerides (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), Malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO) and pancreatic mitochondrial ATPase activity were determined by enzymatic colorimetric methods with commercial kits (BioSino Inc.).

Techniques: Control